Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 2

Effect of RBAEDM on ulcers induced by pyloric ligation.

Treatments	Dose (mg/kg)	Ulcerated surface (mm^2)	Ulcer index	Inhibition (%)	Mucus mass (mg)
Normal control	−	−	−	−	42.67 ± 2.25
Negative control	−	22.40 ± 5.53	4.24 ± 0.51	−	28.28 ± 1.52^##
RBAEDM	100	5.60 ± 0.81	2.56 ± 0.19	39.62	34.48 ± 2.23
RBAEDM	200	8.80 ± 2.63	3.00 ± 0.75	29.24	38.64 ± 2.83
RBAEDM	400	7.60 ± 2.94	2.35 ± 0.58	44.57	65.30 ± 3.83
Ranitidine	50	8.00 ± 1.30	2.78 ± 0.34	34.43	34.12 ± 1.62

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; , , and : significantly different compared with the negative control; : significantly different compared with the normal control.