Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 3

Effect of RBAEDM on gastric acid secretion induced by pyloric ligation.

Treatments	Dose (mg/kg)	VGJ (mL)	pH	Gastric acidity (mEq/L)
Normal control	−	−	−	−
Negative control	−	1.92 ± 0.19	2.46 ± 0.15	7.76 ± 0.14
RBAEDM	100	1.28 ± 0.21	3.69 ± 0.37	4.48 ± 0.42
RBAEDM	200	0.84 ± 0.09	4.38 ± 0.09	4.32 ± 0.42
RBAEDM	400	0.66 ± 0.08	4.25 ± 0.32	4.00 ± 0.50
Ranitidine	50	0.67 ± 0.13	6.08 ± 0.54	6.16 ± 1.55

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; VGJ: volume of gastric juice; , , and : significantly different compared with the negative control.