Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 4

Effect of RBAEDM on PL-induced ulcers combined with histamine.

Treatments	Dose (mg/kg)	Ulcerated surface (mm^2)	Ulcer index	Inhibition (%)	Mucus mass (mg)
Normal control	−	−	−	−	42.67 ± 2.25
Negative control	−	28.40 ± 2.46	4.63 ± 0.18	−	48.02 ± 3.60
RBAEDM	200	20.20 ± 1.39	4.19 ± 0.13	9.50	49.14 ± 3.79
RBAEDM	400	3.60 ± 1.50	2.20 ± 0.20	52.48	72.63 ± 2.65
Ranitidine	50	12.40 ± 1.36	3.23 ± 0.34	30.23	46.86 ± 6.82

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; and : significantly different compared with the negative control.