Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 5

Gastric acid hypersecretion induced by pyloric ligation combined with histamine.

Treatments	Dose (mg/kg)	VGJ (mL)	pH	Gastric acidity (mEq/L)	IPA (%)
Normal control	−	−	−	−	−
Negative control	−	2.68 ± 0.53	2.70 ± 0.37	24.40 ± 2.92	−
RBAEDM	200	0.90 ± 0.40	4.40 ± 0.88	15.60 ± 2.40	38.79
RBAEDM	400	0.64 ± 0.18	5.81 ± 0.51	13.20 ± 3.00	43.10
Ranitidine	50	1.58 ± 0.22	2.55 ± 0.18	19.60 ± 1.60	22.41

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; VGJ: volume of gastric juice, IPA: inhibition of pepsin activity; and : significantly different compared with the negative control.