Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 6

Effects of RBAEDM on gastric ulcers induced pyloric ligation associated with carbachol.

Treatments	Dose (mg/kg)	Ulcerated surface (mm^2)	Ulcer index	Inhibition (%)	Mucus mass (mg)
Normal control	−	−	−	−	42.67 ± 2.25
Negative control	−	22.60 ± 1.28	4.67 ± 0.28	−	35.84 ± 3.55
RBAEDM	200	8.80 ± 0.80	2.58 ± 0.30	44.75	77.30 ± 4.11
RBAEDM	400	7.40 ± 0.60	1.89 ± 0.10	59.52	84.48 ± 2.55
Verapamil	50	12.20 ± 0.66	2.29 ± 0.15	50.96	39.52 ± 1.25

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; : significantly different compared with the negative control.