Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 7

Gastric acid hypersecretion induced by pyloric ligation associated with carbachol.

Treatments	Dose (mg/kg)	VGJ (mL)	pH	Gastric acidity (mEq/L)	IPA (%)
Normal control	−	−	−	−	−
Negative control	−	3.16 ± 0.25	1.92 ± 0.13	30 ± 3.34	−
RBAEDM	200	2.60 ± 0.54	2.09 ± 0.22	18.40 ± 0.74	32.52
RBAEDM	400	1.88 ± 0.54	2.47 ± 0.36	18.00 ± 0.63	34.95
Verapamil	50	1.80 ± 0.53	3.42 ± 0.85	21.20 ± 2.33	12.19

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; VGJ: volume of gastric juice; IPA: inhibition of pepsin activity; : significantly different compared with the negative control.