Antihistaminergic and Anticholinergic Properties of the Root Bark Aqueous Extract of Diospyros mespiliformis (Ebenaceae) on Hypersecretion of Gastric Acid Induced in Wistar Rats

Table 8

Effect of RBAEDM on some parameters of oxidative stress and nitrites.

Treatment	Dose (mg/kg)	MDA (μmol/mg protein)	SOD (U/mg protein)	CAT (μmol H2O2/min/mg protein)	GSH (mmol/g protein)	Nitrites (mol/L)
Normal control	−	2.03 ± 0.52	225.55 ± 4.15	80.09 ± 5.36	4.23 ± 5.14	5.01 ± 0.86
Negative control	−	2.50 ± 0.10^#	214.00 ± 6.83	77.10 ± 4.12	4.59 ± 4.39	5.56 ± 0.37
RBAEDM	100	2.11 ± 0.68	224.00 ± 3.23	79.23 ± 1.28	5.83 ± 1.58	8.10 ± 0.98
RBAEDM	200	2.14 ± 0.10	229.60 ± 2.00	91.27 ± 1.93	5.90 ± 2.05	8.36 ± 0.62
RBAEDM	400	1.97 ± 0.92	221.80 ± 4.18	96.30 ± 5.81	5.00 ± 1.73	9.94 ± 0.92
Ranitidine	50	2.06 ± 0.12	216.60 ± 4.70	87.87 ± 4.35	5.79 ± 4.27	5.17 ± 0.16

N = 5: number of animals per group. Values are expressed as mean ± standard error of the mean; RBAEDM: root bark aqueous extract of Diospyros mespiliformis; MDA : malondialdehyde; SOD : superoxide dismutase; CAT : catalase; GSH : reduced glutathione; , , and : significantly different compared with the negative control; : significantly different compared with normal control.