Irisin Activates M1 Macrophage and Suppresses Th2-Type Immune Response in Rats with Pelvic Inflammatory Disease

Figure 1

Effect of irisin on rat serum cytokines. (a ∼ d) Levels of IL-6, IL-8, TNF-α, and NF-kB in the rat serum were determine by ELISA (“” indicates a statistical difference from the sham group,  < 0.001; “###” indicates a statistical difference from the APID group,  < 0.001. “&” indicates a statistical difference from the sham group,  < 0.05; “&&” indicates a statistical difference from the sham group,  < 0.01).

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