Actinidia deliciosa Mitigates Oxidative Stress and Changes in Pancreatic α-, β-, and δ-Cells and Immunohistochemical and Histological Architecture in Diabetic Rats

Figure 2

Immunohistochemical photomicrograph showed normal rat pancreas (G1, (a)) with dark intensity positive immunostaining of insulin antibody in islet (I) and presence of β-cells (B) and negative in Alpha- (A) and Delta-cells (D) as well as acini (AC) and blood vessels (BV). The pancreas of rats administered with Actinidia deliciosa (G2, (b)) shows the moderate positive immunostaining of insulin in most β-cell expressed in the cytoplasm and absent insulin in the area of Alpha- (A) and Delta-cells (D) and presence of blood capillaries (BC) and negative epithelial cells of pancreatic acini (AC). Diabetic rats (G3, (c)) show proliferating and crowded β-cells in islet with a decrease of the positive immunostaining of the insulin at periphery cells (+B), negative blue β-cell (−B), D-cell, and α-cell (A), and increased dilated blood vessels (BV). Diabetic rats supplemented with Actinidia deliciosa (G4, (d)) show improved β-cell with moderate positivity diffuse immunostaining of the insulin on β-cells (+B).