Isoschaftoside Inhibits Lipopolysaccharide-Induced Inflammation in Microglia through Regulation of HIF-1α-Mediated Metabolic Reprogramming

Figure 5

Isoschaftoside inhibits the activation of ERK1/2/mTOR pathway in microglia. (a–c) Expression of ERK1/2 and mTOR after 9 h of treatment with lipopolysaccharide (10 ng/mL) and isoschaftoside (200 μM). (d–f) And when the cells were treated with CoCl₂, isoschaftoside also inhibited the activation of ERK1/2/mTOR pathway in microglia. Data are means ± SD; , , for comparisons shown, n = 3. Statistical analyses were done by using two-way ANOVA with the Tukey’s post hoc test.

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