Identification of Key Drug Targets and Molecular Mechanisms of Curcumae Rhizoma Acting on HBV-Related HCC: Weighted Correlation Network and Network Pharmacological Analyses

Table 3

Enriched GO-BP and KEGG terms of potential targets.

Ontology	ID	Description	GeneRatio	BgRatio	value	P adjust	Q value	GeneID	Count	Zscore
BP	GO:0044774	Mitotic DNA integrity checkpoint	4/11	106/18670	3.14e − 07	1.88e − 04	9.49e − 05	TOP2A/CDK1/AURKA/PRKDC	4	2
BP	GO:0048511	Rhythmic process	5/11	295/18670	4.07e − 07	1.88e − 04	9.49e − 05	TOP2A/ESR1/CDK1/SERPINE1/PRKDC	5	0.447213595
BP	GO:0031570	DNA integrity checkpoint	4/11	157/18670	1.52e − 06	4.10e − 04	2.07e − 04	TOP2A/CDK1/AURKA/PRKDC	4	2
BP	GO:0007093	Mitotic cell cycle checkpoint	4/11	165/18670	1.85e − 06	4.10e − 04	2.07e − 04	TOP2A/CDK1/AURKA/PRKDC	4	2
BP	GO:0007623	Circadian rhythm	4/11	208/18670	4.65e − 06	4.10e − 04	2.07e − 04	TOP2A/CDK1/SERPINE1/PRKDC	4	1
BP	GO:0000075	Cell cycle checkpoint	4/11	216/18670	5.40e − 06	4.10e − 04	2.07e − 04	TOP2A/CDK1/AURKA/PRKDC	4	2
BP	GO:0018105	Peptidyl-serine phosphorylation	4/11	299/18670	1.95e − 05	1.00e − 03	5.04e − 04	CDK1/PTGS2/AURKA/PRKDC	4	1
BP	GO:0007568	Aging	4/11	321/18670	2.57e − 05	0.001	5.78e − 04	CDK1/PTGS2/SERPINE1/PRKDC	4	0
BP	GO:0018209	Peptidyl-serine modification	4/11	322/18670	2.60e − 05	0.001	5.78e − 04	CDK1/PTGS2/AURKA/PRKDC	4	1
BP	GO:0045930	Negative regulation of mitotic cell cycle	4/11	338/18670	3.15e − 05	0.001	6.68e − 04	TOP2A/CDK1/AURKA/PRKDC	4	2
KEGG	hsa05204	Chemical carcinogenesis	3/11	82/8076	1.57e − 04	0.008	0.006	CYP2C19/PTGS2/ADH1C	3	−1.73205081
KEGG	hsa04913	Ovarian steroidogenesis	2/11	51/8076	0.002	0.044	0.035	PTGS2/HSD17B2	2	−1.41421356
KEGG	hsa00590	Arachidonic acid metabolism	2/11	63/8076	0.003	0.044	0.035	CYP2C19/PTGS2	2	−1.41421356
KEGG	hsa00982	Drug metabolism-cytochrome P450	2/11	71/8076	0.004	0.044	0.035	CYP2C19/ADH1C	2	−1.41421356
KEGG	hsa04115	p53 signaling pathway	2/11	73/8076	0.004	0.044	0.035	CDK1/SERPINE1	2	0