[Retracted] SERPINE1 Gene Is a Reliable Molecular Marker for the Early Diagnosis of Aortic Dissection

Table 1

The 6 significant genes related to the occurrence of aortic dissection. PLAUR, SERPINA1, SERPINE1, and TIMP1 were significantly upregulated in aortic dissection, and ACTN4 and GAS6 were significantly downregulated.

Gene symbol	Fold change	Gene title	GO—Biological process
ACTN4	0.29	Actinin alpha 4	Actin filament bundle assembly; positive regulation of cell migration [24]; and; regulation of apoptotic process [25]
GAS6	0.47	Growth arrest specific 6	Activation of protein kinase B activity; extracellular matrix assembly; and; negative regulation of apoptotic process [26]
PLAUR	2.34	Plasminogen activator, urokinase receptor	Chemotaxis [27]; fibrinolysis; andnegative regulation of apoptotic process [28];
SERPINA1	2.20	Serpin family A member 1	Acute-phase response; neutrophil degranulation; andnegative regulation of endopeptidase activity [29]
SERPINE1	2.97	Serpin family E member 1	Angiogenesis [30]; extracellular matrix organization; Fibrinolysis [31]; and; regulation of smooth muscle cell migration [32]
TIMP1	2.39	TIMP metallopeptidase inhibitor 1	Extracellular matrix disassembly; negative regulation of apoptotic process; and; negative regulation of metallopeptidase activity [33]