Research Article
Integrating Metabolomics and Network Pharmacology to Explore the Protective Effect of Ginsenoside Re against Radiotherapy Injury in Mice
Table 4
Metabolic pathways associated with potential biomarkers in serum.
| Metabolic pathway | Total | Expected | Hits | Raw p | Holm adjust | FDR | Impact |
| Sphingolipid metabolism | 21 | 0.18 | 3 | 0.00056 | 0.04726 | 0.0269 | 0.158 | Linoleic acid metabolism | 5 | 0.04 | 2 | 0.00064 | 0.05317 | 0.0269 | 1.0 | Glycerophospholipid metabolism | 36 | 0.30 | 3 | 0.00281 | 0.23015 | 0.0786 | 0.216 | Fatty acid biosynthesis | 47 | 0.39 | 3 | 0.00604 | 0.48925 | 0.1268 | 0.015 | Biosynthesis of unsaturated fatty acids | 36 | 0.30 | 2 | 0.03484 | 1.0 | 0.4878 | 0.0 | Arachidonic acid metabolism | 36 | 0.30 | 2 | 0.03484 | 1.0 | 0.4878 | 0.020 | Alpha-linolenic acid metabolism | 13 | 0.11 | 1 | 0.10409 | 1.0 | 1.0 | 0.0 | Glycosylphosphatidylinositol (GPI)-anchor biosynthesis | 14 | 0.12 | 1 | 0.11167 | 1.0 | 1.0 | 0.004 | Glutathione metabolism | 28 | 0.23 | 1 | 0.21173 | 1.0 | 1.0 | 0.027 | Fatty acid elongation | 39 | 0.33 | 1 | 0.28293 | 1.0 | 1.0 | 0.0 | Fatty acid degradation | 39 | 0.33 | 1 | 0.28293 | 1.0 | 1.0 | 0.0 |
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