3β,23-Dihydroxy-12-ene-28-ursolic Acid Isolated from Cyclocarya paliurus Alleviates NLRP3 Inflammasome-Mediated Gout via PI3K-AKT-mTOR-Dependent Autophagy

Figure 9

Effects of I3K-AKT-mTOR signal pathway on intracellular ROS and IL-1β production. (a) The levels of ROS in the intracellular. (b) The relative expression levels of ROS. (c) The levels of IL-1β in the supernatants. The values are expressed as mean ± SD. ^## < 0.01 compared with the control group.  < 0.01 compared with the model group. ^&& < 0.01 compared with compound 2 (5 μM) group.

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