Therapeutic Effect of Catgut Implantation at Acupoint in a Mouse Model of Hepatocellular Carcinoma by Suppressing Immune Escape

Figure 4

Effect of CIAA on immune status in HCC mice. (a) Immunohistochemical results of CD4, CD8, IL-10, PD-1, and CTLA-4 in liver tissue; (b) qPCR results of IL-10, PD-1, and CTLA-4 in liver tissues (mRNA of IL-10 : control vs. HCC,  < 0.0005; HCC vs. CIAA,  < 0.0005; control vs. CIAA,  > 0.05; mRNA of PD-1 : control vs. HCC,  < 0.05; HCC vs. CIAA,  < 0.05; control vs. CIAA,  < 0.01; mRNA of CTLA-4 : control vs. HCC,  < 0.05; HCC vs. CIAA,  < 0.05; control vs. CIAA,  > 0.05).

(a)

(b)