Clerodendrum wallichii Merr Methanol Extract Protected Alcohol-Induced Liver Injury in Sprague-Dawley Rats by Modulating Antioxidant Enzymes

Table 2

Effect of methanol extract of Clerodendrum wallichii (MECW) on oxidative stress in ethanol-induced toxicity of SD rats.

Treatment group (n = 5)	GSH (µg/mg protein)	CAT (IU/mg protein)	SOD (U/mg protein)	MDA (nmol/mg protein)
Nonalcoholic control	7.304 ± 0.284	8.73 ± 0.342	31.57 ± 1.096	1.81 ± 0.050
Alcoholic control (ethanol 1 mL/100 g b.w. of rats)	3.18 ± 0.126^a	4.47 ± 0.234^a	14.57 ± 0.745^a	6.10 ± 0.335^a
C. wallichii (200 mg/kg) + ethanol	4.77 ± 0.277^b	5.59 ± 0.263	24.78 ± 0.693^b	2.30 ± 0.208^b
C. wallichii (400 mg/kg) + ethanol	5.78 ± 0.328^b	6.42 ± 0.305	25.4 ± 0.977^b	2.0 ± 0.107^b
C. wallichii (600 mg/kg) + ethanol	6.57 ± 0.218^b	8.10 ± 0.294^b	28.38 ± 0.321^b	1.90 ± 0.101^b
C. wallichii (800 mg/kg) + ethanol	6.31 ± 0.129^b	7.65 ± 0.337^b	27.72 ± 0.380^b	1.96 ± 0.136^b
C. wallichii (1000 mg/kg) + ethanol	5.87 ± 0.210^b	7.28 ± 0.402	27.36 ± 0.662^b	2.11 ± 0.179^b
Silymarin (25 mg/kg) + ethanol	6.30 ± 0.247^b	7.8 ± 0.314^b	27.52 ± 0.402^b	1.92 ± 0.135^b

Effects of different doses (200–1000 mg/kg) of MECW and silymarin (25 mg/kg) on oxidative stress in alcohol-induced SD rats. GSH: glutathione; CAT: catalase; SOD: superoxide dismutase; MDA: malondialdehyde. ^a,a significantly differs compared to the nonalcoholic control group. ^b,b,b significantly differs compared to the alcoholic control group. The values were reported as the means ± SEM (n = 5 rats/group). were considered to be significant (one-way ANOVA followed by Dunnett T3 Post Hoc test).