The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway

Figure 1

FTZ improves cardiac dysfunction and alleviates cardiac hypertrophy in pressure overload-mediated cardiac dysfunction in mice (a) Representative M-mode echocardiography of the left ventricular chamber. FTZ-L and FTZ-H represent doses of 1.2 and 2.4 g/kg FTZ, respectively. CAPT represents the 10 mg/kg captopril group. (b–f) Echocardiographic assessment of LVIDd, LVIDs, EF%, FS%, and E/A; n = 8 per group. (g) HW/BW ratios in each group; n = 8 per group. Data are presented as the mean ± SEM. versus the sham group and ^# and ^## versus the TAC group.

(a)

(b)

(c)

(d)

(e)

(f)

(g)