The Traditional Chinese Medicine Formula FTZ Protects against Cardiac Fibrosis by Suppressing the TGFβ1-Smad2/3 Pathway

Figure 2

FTZ reduces cardiac fibrosis in pressure-overload mice. (a–d) H&E staining results of cardiac tissue are shown. Scale bars: 50 μm. n = 3 per group. Masson’s trichrome staining results of cardiac tissue are shown. Scale bars: 50 μm. n = 3 per group. Fibrosis of cardiac tissues stained with Sirius Red. Scale bars: 50 μm. n = 3 per group. Immunohistochemical detection of α-SMA. Scale bars, 50 μm. n = 3 per group. (e–g) RT-qPCR to determine Col1A2, Col3, and CTGF expression. n = 6 per group. Data are presented as the mean ± SEM. versus the sham group and ^## versus the TAC group.

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