Evidence-Based Complementary and Alternative Medicine

Research Article

Prediction of the Active Components and Mechanism of Forsythia suspensa Leaf against Respiratory Syncytial Virus Based on Network Pharmacology

Table 1

Main hemical composition of FSL.


NO.	Compound	Molecular formula	Ion mode	Mzmed	RT/min	Peak area

1	(+)-Pinoresinol	C₂₀H₂₂O₆	[M-H]^-	357.13	6.56	791229617.70
2	(+)-Pinoresinol-4-O-beta-D-glucopyraside	C₂₆H₃₂O₁₁1	[M-H]^-	519.19	6.56	4166509751.00
3	Salidroside	C₁₄H₂₀O₇	[M-H]^-	299.11	2.98	416030123.60
4	Quercetin	C₁₅H₁₀O₇	[M + H]⁺	303.05	6.60	883627.57
5	Hyperoside	C₂₁H₂₀O₁₂2	[M-H]^-	463.08	6.08	7594792.25
6	Caffeic acid	C₉H₈O₄	[M-H]^-	179.03	4.01	10694238742.00
7	Phillyrin	C₂₇H₃₄O₁₁1	[M-H]^-	579.20	7.73	7458440880.00
8	Chlorogenic acid	C₁₆H₁₈O₉	[M-H]^-	353.08	3.57	110358675.20
9	Kaempferol	C₁₅H₁₀O₆	[M-H]^-	285.03	8.89	355385.01
10	3-Hydroxybenzaldehyde	C₇H₆O₂	[M-H]^-	121.02	4.21	188945020.50
11	Ferulic acid	C₁₀H₁₀O₄	[M-H]^-	193.04	4.49	4914965.43
12	P-Hydroxyphenyl acrylic acid	C₉H₈O₃	[M-H]^-	163.03	4.65	10697330.91
13	Secoisolariciresinol	C₂₀H₂₆O₆	[M-H]^-	361.16	7.09	9828539.83
14	Calceolarioside B	C₂₃H₂₆O₁₁1	[M + H]⁺	479.16	5.89	675251118.64
15	Vanillic acid	C₈H₈O₄	[M-H]^-	167.03	3.94	48787513.71
16	4-Dicaffeoylquinic acid	C₁₆H₁₈O₉	[M-H]^-	353.08	3.88	80843996.30
17	Quinic acid	C₇H₁₂O₆	[M-H]^-	191.05	4.57	57466022.97
18	3,4-Dihydroxybenzaldehyde	C₇H₆O₃	[M-H]^-	137.02	4.00	60332307.59
19	Phillyrin B	C₃₄H₄₄O₁₉9	[M-H]^-	755.23	6.00	820467980.90
20	4-Hydroxycinnamic acid	C₉H₈O₃	[M-H]^-	163.03	5.27	250776002.80
21	Rhamnocitrin	C₂₀H₂₂O₆	[M-H]^-	357.13	27.22	22984449.73
22	P-hydroxybenzoxal	C₇H₆O₂	[M-H]⁺	123.04	0.87	24287717.24
23	Benzoic acid	C₇H₆O₂	[M + H]⁺	123.04	3.64	40801996.94
24	Isophorone	C₉H₁₄O	[M-H]⁺	139.11	2.79	116897843.36
25	Nivolumab	C₈H₈O₃	[M + H]⁺	153.06	5.21	62982567.92
26	Camphor	C₁₀H₁₆O	[M + H]⁺	153.13	5.84	106102205.21
27	Tryptamine	C₁₀H₁₂N₂	[M + H]⁺	161.11	26.80	7964958.56
28	2-Coumarin	C₉H₈O₃	[M + H]⁺	165.06	3.83	43963794.17
29	P-Hydroxycinnamic acid	C₉H₈O₃	[M + H]⁺	165.06	4.58	9310132.79
30	Paeonol	C₉H₁₀O₃	[M + H]⁺	167.07	3.22	30106741.86
31	Homogentisic acid	C₈H₈O₄	[M + H]⁺	169.05	1.24	89280908.15
32	Geranic acid	C₁₀H₁₆O₂	[M + H]⁺	169.12	1.02	56272751.98
33	6,7-Dihydroxy-4-methylcoumarin	C₁₀H₈O₄	[M + H]⁺	193.05	7.40	11318256.46
34	Scopolactone	C₁₀H₈O₄	[M + H]⁺	193.05	0.45	6146412.70
35	Yokogawa ligustilide A	C₁₂H₁₆O₂	[M + H]⁺	193.12	8.71	9992106.14
36	Dihydrokaempferol (colombian aglycone)	C₁₄H₁₄O₄	[M + H]⁺	285.05	1.74	1054100.46
37	Propethrin	C₁₉H₂₆O₃	[M + H]⁺	303.20	7.44	37631362.46
38	Sanguinarine	C₁₅H₁₀O₇	[M + H]⁺	303.05	8.10	44076.10
39	Boswellic acid	C₂₀H₃₀O₂	[M + H]⁺	303.23	12.14	3471892.58
40	(-)-Epigallocatechin	C₁₅H₁₄O₇	[M + H]⁺	307.08	6.12	282532593.99
41	Gallocatechins	C₁₅H₁₄O₇	[M + H]⁺	307.08	4.69	7539336.66
42	Caffeinol	C₂₀H₂₈O₃	[M + H]⁺	317.21	10.82	33616062.68
43	Isorhamnetin	C₁₆H₁₂O₇	[M + H]⁺	317.07	6.46	1930112.37
44	Ginkgoneolic acid	C₂₀H₃₂O₃	[M + H]⁺	321.24	11.45	8274443.51
45	Isoform aconitin	C₂₀H₂₇NO3	[M + H]⁺	330.21	6.89	17743758.07
46	Columbin	C₂₀H₂₂O₆	[M + H]⁺	359.15	6.13	15304281.36
47	Genistein B	C₁₉H₁₈O₇	[M + H]⁺	359.11	1.14	98701853.52
48	Rosmarinic acid	C₁₈H₁₆O₈	[M + H]⁺	361.09	4.57	400615.12
49	Curcumin	C₂₁H₂₀O₆	[M + H]⁺	369.13	9.96	5345129.23
50	Aucubin	C₁₅H₂₂O₉	[M + H]⁺	369.12	2.21	3112265.84
51	Forsytheins	C₂₁H₂₄O₆	[M + H]⁺	373.17	7.78	81425864.68
52	Paraphyllin	C₂₂H₃₃NO4	[M + H]⁺	376.25	4.94	21317926.78
53	Loganic acid	C₁₆H₂₄O₁₀0	[M + H]⁺	377.15	4.69	61961252.11
54	Eleutheroside	C₁₆H₂₂O₉	[M + H]⁺	381.12	2.97	39828726.65
55	Pseudolaric acid C	C₂₁H₂₆O₇	[M + H]⁺	391.18	8.97	33835218.13
56	Afzelin	C₂₁H₂₀O₁₀0	[M + H]⁺	433.11	6.37	1241906.35
57	Astragalin	C₂₁H₂₀O₁₁1	[M + H]⁺	449.11	6.19	5731468.55
58	Isosakuranin	C₂₂H₂₄O₁₀0	[M + H]⁺	449.15	3.63	58302445.74
59	Asperuloside acid	C₁₈H₂₄O₁₂2	[M + H]⁺	455.12	4.25	1549292.02
60	Berberine	C₂₆H₃₀O₇	[M + H]⁺	455.20	7.44	653736.80
61	Forsythoside E	C₂₀H₃₀O₁₂2	[M + H]⁺	463.18	3.20	119659925.90
62	Methylnissolin-3-O-glucoside	C₂₃H₂₆O₁₀0	[M + H]⁺	463.16	6.75	6053442.72
63	Isoquercitrin	C₂₁H₂₀O₁₂2	[M + H]⁺	465.10	6.10	35289037.57
64	Daphylloside	C₁₉H₂₆O₁₂2	[M + H]⁺	469.13	5.22	125152971.49
65	Calceolarioside A	C₂₃H₂₆O₁₁1	[M + H]⁺	501.14	3.20	29042008.47
66	Rutin	C₂₇H₃₀O₁₆6	[M + H]⁺	611.16	5.92	799317923.21
67	Isorhamnetin-3-o-neohesperidin	C₂₈H₃₂O₁₆6	[M + H]⁺	625.18	6.45	3038686.75