Gallic Acid Inhibits Mesaconitine-Activated TRPV1-Channel-Induced Cardiotoxicity

Figure 6

Effect of GA and the coadministrative of MA on the mitochondrial membrane potential and Ca²⁺ release in H9c2 cells. (a) Effects of GA (25, 50, and 100 µM) or pretreatment with BCTC (10 µM) on the decrease of the mitochondrial membrane potential in H9c2 cells induced by 250 µM MA. (b) Effects of GA (25, 50, and 100 µM) or pretreatment with BCTC (10 µM) on the increase of the mean fluorescence intensity of Ca²⁺ in H9c2 cells induced by 250 µM MA. Data are presented as the mean ± SD (n = 3).  < 0.01 versus control group and ^## < 0.01 versus MA group.

(a)

(b)