Inhibition of α-Amylase, α-Glucosidase, and Lipase, Intestinal Glucose Absorption, and Antidiabetic Properties by Extracts of Erodium guttatum

Table 3

Effects of E. guttatum extracts on fasting blood sugar in mice made diabetic by HFD-STZ.

Fasting blood sugar (mg/dL)
	1 st day	30 days
Control normal	94.54 ± 15.32	110.42 ± 21.09
Diabetic control (STZ-HFD)	239.75 ± 26.42ns	295.1 ± 12.38††††ns
Diabetic + metformin (300 mg/kg)	253.17 ± 29.47ns	104.67 ± 4.08####ns
Diabetic + EGA (200 mg/kg)	250.33 ± 11.23ns	102.41 ± 4.22####ns
Diabetic + EGM (200 mg/kg)	236.02 ± 20.12ns	98.3 ± 12.6####ns
Diabetic + EGE (200 mg/kg)	253 ± 29.3ns	100.15 ± 29.14####ns

Values are mean ± SEM (n = 8). compared to the normal control group. ^#### compared to the diabetic control group (HFD-STZ). ^†††† compared to the diabetic + metformin. Ns = not significant to the diabetic + metformin or diabetic control group (HFD-STZ) or normal control. EGA: aqueous extract of E. guttatum; EGM: methanolic extract of E. guttatum; EGE: ethanolic extract of E. guttatum. HFD: high-fat diet. STZ: streptozotocin. present only statistical difference between results. They are explained by P < 0.0001.