Inhibition of α-Amylase, α-Glucosidase, and Lipase, Intestinal Glucose Absorption, and Antidiabetic Properties by Extracts of Erodium guttatum
Table 5
Effects of E. guttatum extracts on hematological and biochemical parameters in mice made diabetic by HFD-STZ.
Normal control
Diabetic control (STZ-HFD)
Diabetic + metformin (300 mg/kg)
Diabetic + EGA (200 mg/kg)
Diabetic + EGM (200 mg/kg)
Diabetic + EGE (200 mg/kg)
Hematology
WBC (10−3/μL)
4.23 ± 0.89
21.31 ± 3.69†
10.43 ± 5.43#ns
9.22 ± 1.89#ns
7.86 ± 5.37##ns
7.33 ± 2.1##ns
RBC (10−6/μL)
6.87 ± 0.02
8.36 ± 0.59 ns
7.84 ± 0.21 ns
9.90 ± 0.97†ns
8.88 ± 0.62ns
9.18 ± 0.65ns
HGB (g/dL)
11.25 ± 0.49
14.32 ± 1.27 ns
12.93 ± 0.98 ns
14.22 ± 1.35 ns
13.03 ± 0.55 ns
13.07 ± 0.66 ns
PLT (10−3/μL)
508.00 ± 89.7
516.75 ± 93.11 ns
534.3 ± 51.18 ns
766.3 ± 339.9 ns
284.3 ± 103.2 ns
750 ± 232.1 ns
Lipid profile
Cholesterol (g/L)
0.7 ± 0.01
3.48 ± 0.25
0.46 ± 0.17ns
1 ± 0.56ns
1.33 ± 0.19#ns
1.15 ± 0.16ns
TG (g/L)
0.83 ± 0.31
2.3 ± 0.26††
0.41 ± 0.16 ns##
1.77 ± 0.83†ns
2.2 ± 0.34††ns
1.59 ± 0.66 ns
HDL (mMol/L)
0.36 ± 0.06
0.14 ± 0.04 ns
0.21 ± 0.05 ns
0.49 ± 0.15#ns
0.4 ± 0.21 ns
0.46 ± 0.08#ns
LDL (g/L)
0.01 ± 0.001
0.26 ± 0.05
0.21 ± 0.09 ns
0.06 ± 0.01##†ns
0.14 ± 0.02 ns#
0.14 ± 0.01 ns#
Liver function
AST (UI/L)
121.65 ± 5.28
266.17 ± 13.44 ns
118.33 ± 33.26 ns
176.5 ± 51.61 ns
483 ± 162.6#†††
218.5 ± 13.43 ns
ALT (UI/L)
39.27 ± 3.6
127.67 ± 12.5ns
84.66 ± 17.62 ns
55.33 ± 25.0 ns
70.33 ± 52.5 ns
61.5 ± 29.8 ns
Renal function
Urea (g/L)
0.59 ± 0.07
0.62 ± 0.12 ns
0.43 ± 0.09 ns
0.34 ± 0.11 ns
0.51 ± 0.24 ns
0.35 ± 0.08 ns
Creatinine (mg/L)
3.78 ± 0.27
7.70 ± 1.49†††
4.18 ± 0.22###ns
3.30 ± 0.28####ns
4.1 ± 0.69###ns
3.43 ± 0.41####ns
The values are the mean ± SEM (n = 6). ,,, and compared to the normal control group. #,##,###, and #### compared to the diabetic control group (HFD-STZ). †,††, and ††† compared to the diabetic + metformin. Ns = not significant to the diabetic + metformin or diabetic control group (HFD-STZ). EGA: aqueous extract of E. guttatum; EGM: methanolic extract of E. guttatum; EGE: ethanolic extract of E. guttatum.
