Luteolin Ameliorates Methamphetamine-Induced Podocyte Pathology by Inhibiting Tau Phosphorylation in Mice

<div>Lithium chloride rescued methamphetamine-induced podocyte protein loss and podocyte apoptosis. (a) Representative micrographs of synaptopodin immunohistochemistry staining in mouse kidneys. (b) Analysis of synaptopodin intensity in each group. (c) Representative micrographs of podocalyxin-like protein 1 immunohistochemistry staining in mouse kidneys. (d) Analysis of podocalyxin-like protein 1 intensity in each group. (e) Representative micrographs of TUNEL staining in mouse kidneys. 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103S58 78 58 46C58 11 82 -12 113 -12Z"></path></g><g transform="matrix(.013,0,0,-0.013,49.05,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,55.29,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,61.53,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> by one-way ANOVA and Bonferroni post hoc analysis. <i>n</i> = 6 per group.</div>

Evidence-Based Complementary and Alternative Medicine

fig6

Figure 6

Figure 6: Luteolin Ameliorates Methamphetamine-Induced Podocyte Pathology by Inhibiting Tau Phosphorylation in Mice 