Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease
Table 4
The differential metabolites between HQII group and Control group.
Name
m/z1
RT2 (min)
VIP
value
LogFC3
AUC4
3-Phenyllactic acid
165.06
5.21
1.56
2.48E-02
−4.29
0.777
Palmitic acid
255.23
5.51
2.59
1.10E-12
−3.99
1.000
Stearic acid
283.26
2.66
1.62
2.31E-04
−3.50
0.759
Palmitoleic acid
253.21
2.38
2.02
2.91E-07
−3.39
0.982
Deoxycholate
391.28
7.82
1.21
2.55E-02
−3.23
0.835
Naringenin
271.06
7.59
1.38
2.69E-02
2.99
0.697
Linoleic acid
279.23
2.38
2.19
3.01E-06
−2.54
0.963
Daidzein
253.05
8.81
1.61
9.13E-04
2.51
0.795
Maltitol
343.12
12.51
1.55
1.22E-02
−2.29
0.827
2-isopropylmalic acid
175.06
10.09
1.91
7.79E-05
−2.17
0.879
Oleic acid
281.25
2.47
1.95
1.86E-06
−2.00
0.926
Pyridoxine
168.07
5.49
2.03
3.05E-05
−1.99
0.896
Azelaic acid
187.10
4.20
1.88
1.59E-04
−1.87
0.841
Ala-Ala
159.08
12.17
2.35
5.21E-07
−1.72
0.958
Genistein
269.04
7.85
1.06
2.36E-02
1.71
0.719
Pimelic acid
159.07
10.52
1.72
1.49E-03
−1.71
0.846
L-Cystine
239.02
14.28
1.65
2.01E-03
−1.65
0.815
4-hydroxybenzoic acid
137.02
6.98
1.92
1.42E-07
−1.61
0.875
Phenylacetylglycine
192.07
6.57
1.59
1.85E-03
−1.53
0.796
Citrulline
174.09
12.40
1.08
3.26E-02
−1.52
0.699
3-oxyanthranilic acid
152.03
3.28
1.69
1.18E-05
1.50
0.774
Lactulose
341.11
11.72
1.65
1.77E-02
−1.50
0.847
Taurocholic acid
514.28
7.21
1.55
4.97E-06
1.49
0.875
Hypoxanthine
135.03
6.86
1.98
1.38E-05
1.47
0.890
DHEA sulfate
367.16
2.07
1.93
2.94E-05
1.47
0.839
Allantoin
157.04
7.46
1.89
8.08E-05
−1.41
0.833
Indolelactic acid
204.07
5.72
1.36
2.25E-02
−1.38
0.743
3-hydroxybenzaldehyde
121.03
5.56
1.38
3.31E-04
−1.30
0.761
Threonic acid
135.03
10.99
1.31
1.28E-03
−1.30
0.755
L-homocarnosine
239.11
12.88
1.04
6.95E-03
−1.30
0.670
3′-AMP
346.04
6.04
1.90
1.08E-06
−1.26
0.917
N2-acetylornithine
173.09
10.18
1.77
4.10E-06
−1.18
0.848
Uridine
243.06
6.85
1.26
3.93E-02
1.18
0.755
Dopamine
152.07
6.41
2.27
7.19E-09
−1.13
0.950
N-isovalerylglycine
158.08
6.89
1.21
6.76E-03
1.11
0.682
Gluconic acid
195.05
12.51
1.05
1.54E-02
−1.10
0.714
Salicylic alcohol
123.05
5.53
1.59
1.54E-05
−1.04
0.848
L-glutamate
146.06
5.47
1.10
8.19E-03
−1.00
0.790
Sebacic acid
201.11
3.94
1.27
3.72E-03
−0.96
0.726
Uracil
111.02
5.00
1.69
1.67E-04
0.96
0.803
Methionine
148.04
9.77
1.72
4.49E-07
−0.94
0.906
Sinapic acid
223.06
5.53
1.66
2.25E-02
−0.93
0.806
L-gulonolactone
177.04
6.25
1.41
1.53E-05
−0.93
0.829
N-acetyl-L-glutamic acid
188.06
12.55
1.45
6.72E-05
−0.92
0.795
Citric acid
191.02
11.29
1.94
3.61E-06
−0.91
0.900
Guanine
150.04
8.40
1.54
6.75E-06
0.90
0.835
3-methyladipic acid
159.07
10.59
1.05
1.32E-02
0.89
0.736
L-cystathione
221.06
14.11
1.36
7.06E-04
−0.89
0.764
Leucine
130.09
7.57
1.46
3.88E-02
−0.85
0.782
Citraconic acid
129.02
12.70
1.42
1.54E-04
−0.85
0.789
Glycyl-L-proline
171.08
12.07
1.67
4.52E-05
−0.84
0.851
SAH
383.11
12.30
1.54
8.69E-05
−0.82
0.823
4-acetamidobutyric acid
144.07
6.70
1.42
1.56E-06
−0.79
0.859
Hydroxyisocaproic acid
131.07
4.26
1.17
1.80E-03
−0.76
0.728
N-acetyl-L-aspartic acid
174.04
12.58
1.15
5.31E-03
−0.69
0.714
Xylitol
151.06
8.83
1.00
3.49E-02
0.68
0.655
6-phosphogluconic acid
194.93
13.81
1.32
2.70E-03
−0.66
0.719
Citramalic acid
147.03
5.51
1.49
4.65E-05
−0.65
0.824
Ascorbic acid
175.02
1.85
1.03
2.95E-02
0.64
0.728
N-acetylneuraminic acid
308.10
12.29
1.09
1.89E-03
−0.62
0.740
Asp-Glu
261.07
14.19
1.20
1.28E-03
−0.60
0.731
Dicrotalic acid
161.04
12.43
1.27
4.06E-03
−0.60
0.730
Isospaglumic acid
303.08
13.70
1.01
1.52E-02
−0.59
0.689
Serine
104.04
12.14
1.09
3.71E-03
0.51
0.736
Cinnamic acid
147.04
9.03
1.05
4.59E-03
−0.41
0.736
3′-O-methylguanosine
296.10
8.30
1.12
3.91E-02
0.37
0.661
1mass-to-charge ratio; 2retention time; 3logarithm of fold change based on two; 4area under the curve in receiver operating characteristic curve analysis.
