Research Article

Paclitaxel Resistance Modulated by the Interaction between TRPS1 and AF178030.2 in Triple-Negative Breast Cancer

Figure 2

Upregulation of lncRNA AF178030.2 and its clinical outcome in paclitaxel-resistant TNBC patients. (a) Quantitative real-time PCR showing eight lncRNAs expression, including BC015064, AF178030.2, AM259138, SND1, AK129540, AC073934.6, NR_024579, and NR_023391 between MDA-MB-231R and MDA-MB-231P cells. (b) The expression level of AF178030.2 was determined by quantitative real-time PCR after different days treatment with 1 μM paclitaxel in MDA-MB-231 cells. versus control group. (c) Comparison of AF178030.2 expression level in chemotherapy-resistant patients of TNBC compared to chemotherapy-sensitive patients; all the data were retrieved from the METABRIC database. (d). Kaplan–Meier survival curves of TNBC patients undergoing chemotherapy with low and high AF178030.2 expression based on METABRIC database ().