Research Article

Paclitaxel Resistance Modulated by the Interaction between TRPS1 and AF178030.2 in Triple-Negative Breast Cancer

Figure 3

Overexpression of AF178030.2 attenuated the sensitivity of TNBC to paclitaxel, whereas knockdown of AF178030.2 enhanced the sensitivity of TNBC cells to paclitaxel. (a) Quantitative PCR result showing the expression level of AF178030.2. (b) MTT assay showing the cell viability. (c) Left: representative results of colony formation assay; right: the collective data of colony number after AF178030.2 overexpression. (d) Quantitative PCR result showing the knockdown effect of AF178030.2 by two separate siRNAs. (e) MTT assay showing the cell viability after AF178030.2 knockdown. (f) Colony formation assay showing the colony number after AF178030.2 knockdown. . n = 5.