Review Article

Effect of Traditional Chinese Medicine on Treating Antibiotic-Associated Diarrhea in Children: A Systematic Review and Meta-Analysis

Table 2

Summary of included studies.

Author, yearSample sizeInterventionsControlTreatment courseOutcome
TCMCG

Zhu Hong, 20204342Shenling Baizhu granule + aa2 weeks①④
Yao Na, 20194242Shenling Baizhu granule + aa5 days①②⑤⑥
Wang Fuhai, 20203838Shenling Baizhu granule + aa5 days②③④⑤⑦⑧
Luo Linlin, 20146060Shenling Baizhu granule + aa5 days①②⑥
Shou-Xin Wang, 20206060Xingpi Yanger granule + aa7 days①②⑤⑪
Tian Tian, 20188580Xingpi Yanger granule + aa5-7 days①②③⑧⑫⑬
Huijuan Qi, 20204242Xingpi Yanger granule + aa5 days①⑤⑨⑪⑫
LinJian Ying, 20195353Xingpi Yanger granule + aa3 days
Rong Li, 20202525Xingpi Yanger granule + aa3∼5 days①②⑫⑬
Liu Huijin, 20174848Xingpi Yanger granule + aa7 days①②⑧
Zhang Minzhen, 20183939Jianpi Bushen decoction + aa7 days①②③
Fan Zhang, 20214941Erxieting granules + aa72 h①②③⑤⑨
Cao fang, 201610060Erxieting granules + aa72 h
Yuan Chaogang, 20226060Huangqi Jianzhong decoction + aa6 days①②⑤
Yang Liping, 20165050Weichangan pill + aa7 days①②③⑮
Guo Xinning, 20165850Weichangan pill + aa7 days①②
Ma Jingyan, 20175152Weichangan pill + aa7 days
Chun-Ling Yang, 20173535Jianpi Bushen decoction + aa72 h①②
Yong-jun xu, 20158458Sijunzi decoction + aa5–10 days①②
Tu Xufei, 20205454Modified Yigong powder + aa7 days①⑤③
RuanXiaoDong, 20195757Xiaoer Fuxie powder + aa2 weeks①②⑬⑨⑩
Bai jin, 20175656Xiaoer Fuxie powder + aa2 weeks①②⑬⑨⑩
Li-fang cao, 20174343Yiersan + aa5 days
Ma Xiaopeng, 20166060Guben Yichang tablets + aa2 weeks①②④⑦⑬⑨
Fan Jiayu, 20212525Buzhong Yiqi particles+ aa1 week
Li-fang cao, 20154544Qiweibaizhu powder+aa10 days

a: conventional therapy: antidiarrheal, fluid, diet adjustment, correct electrolyte imbalance, probiotics, montmorillonite powder, and so on; CG: control group. ①total effective rate; ②Antidiarrheal time; ③Diarrhea frequency; ④T cell subset: CD3+, CD4 +, CD8 +, CD4 +/CD8 +; ⑤The time to change the shape of feces; ⑥Time for bowel sounds to return to normal; ⑦Immune indice: CD3+, CD4+, IgA, IgG, IgM; ⑧intestinal barrier function: bacterial endotoxin(BT), diamine oxidase(DAO), D-Lactic acid(D-LC); ⑨Vomiting improvement time; ⑩Inflammatory factors: hs-CRP, IL8, IL-12, and TNF-α; ⑪Gastrointestinal hormones: gastrin(GAS), motilin(MOT), somatostatin(SS); ⑫Average hospital stay; ⑬Normal temperature time.