Simvastatin Inhibits Endometrial Cancer Malignant Behaviors by Suppressing RAS/Mitogen-Activated Protein Kinase (MAPK) Pathway-Mediated Reactive Oxygen Species (ROS) and Ferroptosis

Figure 1

Simvastatin inhibits the proliferation, colony formation, and invasion of Ishikawa cells. (a): MTT to detect the proliferation of Ishikawa cells treated with simvastatin in different concentrations; (b–c): colony formation assay to measure the clone formation of Ishikawa cells treated with simvastatin in different concentrations; (d–e): transwell to detect the invasion of Ishikawa cells treated with simvastatin in different concentrations, and vs. control group; ^## vs. 5 μM group.

(a)

(b)

(c)

(d)

(e)