Simvastatin Inhibits Endometrial Cancer Malignant Behaviors by Suppressing RAS/Mitogen-Activated Protein Kinase (MAPK) Pathway-Mediated Reactive Oxygen Species (ROS) and Ferroptosis

Figure 5

RAS agonist reverses the inhibitory effects of simvastatin on Ishikawa cell proliferation, colony formation, and invasion. (a): MTT assay to detect the effect of simultaneous treatment of ML-098 and simvastatin on the proliferation of Ishikawa cells; (b–c): colony formation assay to explore the effect of simultaneous treatment of ML-098 and simvastatin on the colony formation ability of Ishikawa cells; (d–e): transwell assay to detect the effect of simultaneous treatment of ML-098 and simvastatin on the invasion ability of Ishikawa cells, vs. control group; ^## vs. simvastatin group.

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