|
| Pathway | Total | Hits | Raw p | −ln (p) | Holm adjust | FDR | Impact | Hits cpd | Total cpd |
|
| Histidinemetabolism | 15 | 2 | 0.011526 | 4.4632 | 0.95 | 0.94512 | 0.24194 | L-Histidine cpd:C00135; carnosine cpd: C00386 | L-glutamic acid cpd: C00025; 4-imidazolone-5-propionic acid cpd: C03680; urocanic acid cpd: C00785; L-histidine cpd: C00135; imidazole-4-acetaldehyde cpd: C05130; 1-methylhistamine cpd: C05127; methylimidazole acetaldehyde cpd: C05827; histamine cpd: C00388; carnosine cpd: C00386; N-formyl-L-aspartate cpd: C01044; formiminoglutamic acid cpd: C00439; imidazoleacetic acid cpd: C02835; methylimidazoleacetic acid cpd: C05828; L-aspartic acid cpd: C00049; 1-methylhistidine cpd: C01152 |
| Aminoacyl-tRNA biosynthesis | 69 | 3 | 0.039232 | 3.2383 | 1 | 1 | 0 | L-histidine cpd: C00135; L-phenylalanine cpd: C00079; L-methionine cpd: C00073 | L-asparagine cpd: C00152; tRNA(Asn) cpd: C01637; L-histidine cpd: C00135; tRNA(His) cpd: C01643; L-phenylalanine cpd: C00079; tRNA(Phe) cpd: C01648; L-arginine cpd: C00062; tRNA(Arg) cpd: C01636; L-glutamine cpd: C00064; tRNA(Gln) cpd: C01640; L-cysteine cpd: C00097; tRNA(Cys) cpd: C01639; glycine cpd: C00037; tRNA(Gly) cpd: C01642; tRNA(Asp) cpd: C01638; L-aspartic acid cpd: C00049; L-serine cpd: C00065; tRNA(Ser) cpd: C01650; L-methionine cpd: C00073; tRNA(Met) cpd: C01647; L-valine cpd: C00183; tRNA(Val) cpd: C01653; L-alanine cpd: C00041; tRNA(Ala) cpd: C01635; L-lysine cpd: C00047; tRNA(Lys) cpd: C01646; L-isoleucine cpd: C00407; tRNA(Ile) cpd: C01644; tRNA(Leu) cpd: C01645; L-leucine cpd: C00123; L-threonine cpd: C00188; tRNA(Thr) cpd: C01651; tRNA(Trp) cpd: C01652; L-tryptophan cpd: C00078; N10-formyl-thf cpd: C00234; L-methionyl-tRNA cpd: C02430; L-tyrosine cpd: C00082; tRNA(Tyr) cpd: C00787; L-proline cpd: C00148; tRNA(Pro) cpd: C01649; L-glutamic acid cpd: C00025; tRNA(Glu) cpd: C01641; glutaminyl-tRNA cpd: C02282; L-asparaginyl-tRNA(Asn) cpd: C03402; tRNA(Sec) cpd: C16636; L-seryl-tRNA(Sec) cpd: C06481; O-phosphoseryl-tRNA(Sec) cpd: C16638; L-histidyl-tRNA(His) cpd: C02988; L-phenylalanyl-tRNA(Phe) cpd: C03511; L-arginyl-tRNA(Arg) cpd: C02163; L-cysteinyl-tRNA(Cys) cpd: C03125; glycyl-tRNA(Gly) cpd: C02412; L-aspartyl-tRNA(Asp) cpd: C02984; L-seryl-tRNA(Ser) cpd: C02553; L-valyl-tRNA(Val) cpd: C02554; L-alanyl-tRNA cpd: C00886; L-lysyl-tRNA cpd: C01931; L-isoleucyl-tRNA(Ile) cpd: C03127; L-leucyl-tRNA cpd: C02047; L-threonyl-tRNA(Thr) cpd: C02992; L-tryptophanyl-tRNA(Trp) cpd: C03512; tetrahydrofolic acid cpd: C00101; N-formylmethionyl-tRNA cpd: C03294; L-tyrosyl-tRNA(Tyr) cpd: C02839; L-prolyl-tRNA(Pro) cpd: C02702; L-glutamyl-tRNA(Glu) cpd: C02987; L-glutamyl-tRNA(Gln) cpd: C06112; L-aspartyl-tRNA(Asn) cpd: C06113; L-selenocysteinyl-tRNA(Sec) cpd: C06482 |
| Phenylalanine, tyrosine, and tryptophan biosynthesis | 4 | 1 | 0.044453 | 3.1133 | 1 | 1 | 0.5 | L-phenylalanine cpd: C00079 | Phenylpyruvic acid cpd: C00166; L-phenylalanine cpd: C00079; L-tyrosine cpd: C00082; 4-hydroxyphenylpyruvic acid cpd: C01179 |
| D-glutamine and D-glutamate metabolism | 5 | 1 | 0.055273 | 2.8955 | 1 | 1 | 0 | D-glutamine cpd: C00819 | L-glutamic acid cpd: C00025; D-glutamine cpd: C00819; L-glutamine cpd: C00064; oxoglutaric acid cpd: C00026; D-glutamic acid cpd: C00217 |
| Tryptophan metabolism | 40 | 2 | 0.072666 | 2.6219 | 1 | 1 | 0.10987 | L-kynurenine cpd: C00328; acetyl-N-formyl-5-methoxykynurenamine cpd: C05642 | L-tryptophan cpd: C00078; melatonin cpd: C01598; serotonin cpd: C00780; 5-hydroxykynurenamine cpd: C05638; 5-hydroxykynurenine cpd: C05651; 5-hydroxy-L-tryptophan cpd: C00643; L-formylkynurenine cpd: C02700; acetoacetyl-CoA cpd: C00332; (S)-3-hydroxybutanoyl-CoA cpd: C01144; crotonoyl-CoA cpd: C00877; glutaryl-CoA cpd: C00527; oxoadipic acid cpd: C00322; 2-amino-3-carboxymuconic acid semialdehyde cpd: C04409; 3-hydroxyanthranilic acid cpd: C00632; L-kynurenine cpd: C00328; formylanthranilic acid cpd: C05653; L-3-hydroxykynurenine cpd: C03227; 3-hydroxykynurenamine cpd: C05636; indoleacetaldehyde cpd: C00637; 5-hydroxy-N-formylkynurenine cpd: C05648; 5-hydroxyindoleacetaldehyde cpd: C05634; tryptamine cpd: C00398; indoleacrylic acid cpd: C00331; acetyl-N-formyl-5-methoxykynurenamine cpd: C05642; 6-hydroxymelatonin cpd: C05643; N-acetylserotonin cpd: C00978; formyl-5-hydroxykynurenamine cpd: C05647; 4,6-dihydroxyquinoline cpd: C05639; acetyl-CoA cpd: C00024; 2-aminomuconic acid semialdehyde cpd: C03824; 2-aminobenzoic acid cpd: C00108; L-tryptophanyl-tRNA(Trp) cpd: C03512; cinnavalininate cpd: C05640; 4-(2-amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid cpd: C05645; 4-(2-aminophenyl)-2,4-dioxobutanoic acid cpd: C01252; 4,8-dihydroxyquinoline cpd: C05637; indoleacetic acid cpd: C00954; 5-hydroxyindoleacetic acid cpd: C05635; N-methylserotonin cpd: C06212; N-methyltryptamine cpd: C06213 |
| Nitrogen metabolism | 9 | 1 | 0.097415 | 2.3288 | 1 | 1 | 0 | L-histidine cpd: C00135 | Ammonia cpd: C00014; carbon dioxide cpd: C00011; L-glutamic acid cpd: C00025; L-Glutamine cpd: C00064; L-cystathionine cpd: C02291; L-Histidine cpd: C00135; carbamoylphosphate cpd: C00169; carbonic acid cpd: C01353; glycine cpd: C00037 |
| Phenylalanine metabolism | 11 | 1 | 0.11782 | 2.1386 | 1 | 1 | 0.40741 | L-phenylalanine cpd: C00079 | Phenylacetaldehyde cpd: C00601; phenylacetyl-CoA cpd: C00582; L-phenylalanine cpd: C00079; phenylethylamine cpd: C05332; phenylpyruvic acid cpd: C00166; phenylacetic acid cpd: C07086; phenylacetylglycine cpd: C05598; ortho-hydroxyphenylacetic acid cpd: C05852; enol-phenylpyruvate cpd: C02763; 2-phenylacetamide cpd: C02505; L-tyrosine cpd: C00082 |
| Sphingolipid metabolism | 21 | 1 | 0.21351 | 1.5441 | 1 | 1 | 0 | Phytosphingosine cpd: C12144 | Sphinganine cpd: C00836; ceramide 1-phosphate cpd: C02960; sphingosine 1-phosphate cpd: C06124; sphinganine 1-phosphate cpd: C01120; dihydroceramide cpd: C12126; phytoceramide cpd: C12145; SM cpd: C00550; ceramide cpd: C00195; Palmityl-CoA cpd: C00154; L-Serine cpd: C00065; 3-dehydrosphinganine cpd: C02934; galabiosylceramide cpd: C06126; galactosylceramide cpd: C02686; GM4 cpd: C06128; lactosylceramide cpd: C01290; glucosylceramide cpd: C01190; sphingosine cpd: C00319; 3-O-Sulfogalactosylceramide (d18 : : 1/24 : : 0) cpd: C06125; phytosphingosine cpd: C12144; digalactosylceramidesulfate cpd: C06127; O-phosphoethanolamine cpd: C00346 |
| Cysteine and methionine metabolism | 27 | 1 | 0.26616 | 1.3236 | 1 | 1 | 0.08685 | L-methionine cpd: C00073 | 2-Oxo-4-methylthiobutanoic acid cpd: C01180; 1,2-dihydroxy-3-keto-5-methylthiopentene cpd: C15606; 5′-methylthioadenosine cpd: C00170; S-adenosylmethioninamine cpd: C01137; S-adenosylmethionine cpd: C00019; L-cystathionine cpd: C02291; L-homocysteine cpd: C00155; L-serine cpd: C00065; L-methionine cpd: C00073; S-adenosylhomocysteine cpd: C00021; 2,3-diketo-5-methylthiopentyl-1-phosphate cpd: C15650; cysteic acid cpd: C00506; L-cystine cpd: C00491; L-cysteine cpd: C00097; 3-sulfinoalanine cpd: C00606; sulfite cpd: C00094; 3-mercaptopyruvic acid cpd: C00957; 3-methylthiopropionic acid cpd: C08276; 5-methylthioribose 1-phosphate cpd: C04188; 2-ketobutyric acid cpd: C00109; 2-aminoacrylic acid cpd: C02218; 3-sulfopyruvic acid cpd: C05528; thiocysteine cpd: C01962; 3-sulfinylpyruvic acid cpd: C05527; pyruvic acid cpd: C00022; thiosulfate cpd: C00320; 3-mercaptolactic acid cpd: C05823 |
| Glycerophospholipid metabolism | 30 | 1 | 0.29123 | 1.2336 | 1 | 1 | 0.02315 | Glycerophosphocholine cpd: C00670 | Phosphatidylethanolamine cpd: C00350; phosphatidylcholine cpd: C00157; dihydroxyacetone phosphate cpd: C00111; LysoPC (18 : 1(9Z)) cpd: C04230; 1,2-diacyl-sn-glycerol cpd: C00641; citicoline cpd: C00307; phosphorylcholine cpd: C00588; choline cpd: C00114; acetylcholine cpd: C01996; O-phosphoethanolamine cpd: C00346; ethanolamine cpd: C00189; PA (16 : : 0/16 : : 0) cpd: C00416; acyl-CoA cpd: C00040; 1-acyl-sn-glycerol 3-phosphate cpd: C00681; CDP-diacylglycerol cpd: C00269; glycerol 3-phosphate cpd: C00093; 1-acyl-sn-glycero-3-phosphoethanolamine cpd: C04438; 2-acyl-sn-glycero-3-phosphoethanolamine cpd: C05973; 2-acyl-sn-glycero-3-phosphocholine cpd: C04233; CDP-glycerol cpd: C00513; PS (16 : 0/16 : 0) cpd: C02737; phosphatidylglycerol cpd: C00344; dihydroxyacetone phosphate acyl ester cpd: C03372; CDP-ethanolamine cpd: C00570; 1-phosphatidyl-D-myo-inositol cpd: C01194; glycerylphosphorylethanolamine cpd: C01233; glycerophosphocholine cpd: C00670; phosphatidyl-N-methylethanolamine cpd: C01241; phosphatidylglycerophosphate cpd: C03892; cardiolipin cpd: C05980 |
| Arginine and proline metabolism | 44 | 1 | 0.39796 | 0.9214 | 1 | 1 | 0 | N-acetylornithine cpd: C00437 | L-glutamine cpd: C00064; ammonia cpd: C00014; carbamoylphosphate cpd: C00169; ornithine cpd: C00077; citrulline cpd: C00327; L-aspartic acid cpd: C00049; argininosuccinic acid cpd: C03406; L-arginine cpd: C00062; L-glutamic acid cpd: C00025; N-acetylornithine cpd: C00437; L-proline cpd: C00148; peptide cpd: C00012; D-proline cpd: C00763; hydroxyproline cpd: C01157; pyrroline hydroxycarboxylic acid cpd: C04281; L-4-hydroxyglutamate semialdehyde cpd: C05938; L-erythro-4-hydroxyglutamate cpd: C05947; N-(o)-hydroxyarginine cpd: C05933; guanidinoacetic acid cpd: C00581; creatine cpd: C00300; gamma-aminobutyric acid cpd: C00334; agmatine cpd: C00179; L-glutamic-gamma-semialdehyde cpd: C01165; L-glutamic acid 5-phosphate cpd: C03287; (S)-1-pyrroline-5-carboxylate cpd: C03912; putrescine cpd: C00134; 4-aminobutyraldehyde cpd: C00555; S-adenosylmethioninamine cpd: C01137; S-adenosylmethionine cpd: C00019; spermidine cpd: C00315; N-acetylputrescine cpd: C02714; N4-acetylaminobutanal cpd: C05936; cis-4-hydroxy-D-proline cpd: C03440; fumaric acid cpd: C00122; urea cpd: C00086; N-acetyl-L-alanine cpd: C00624; 1-pyrroline-2-carboxylic acid cpd: C03564; D-4-hydroxy-2-oxoglutarate cpd: C05946; nitric oxide cpd: C00533; phosphocreatine cpd: C02305; 4-guanidinobutanoic acid cpd: C01035; spermine cpd: C00750; 4-acetamidobutanoic acid cpd: C02946; 1-pyrroline-4-hydroxy-2-carboxylate cpd: C04282 |
| Pathway | Metabolic pathway name |
| Total | The number of metabolites in this pathway |
| Hits | The number of differential metabolites hit this pathway |
| Raw p | value of metabolic pathway enrichment analysis |
| −ln(p) | Minus log base E of P |
| Holm adjust | values corrected by Holm–Bonferroni method for multiple hypothesis testing |
| FDR | value corrected by false discovery rate (FDR) method for multiple hypothesis testing |
| Impact | Impact value of metabolic pathway topology analysis |
| Hits cpd | The names and KEGG IDs of differential metabolites hit the pathway |
| Total cpd | All metabolite names and KEGG IDs contained in this pathway |
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