Shipi Shugan Decoction Protected against Sequela of Pelvic Inflammatory Disease via Inhibiting SIRT1/NLRP3 Signaling Pathway in Pelvic Inflammatory Disease Rats

Figure 2

SSD dose-dependently inhibited mitochondrial dysfunction and oxidative stress of SPID rats. (a) The compromised mitochondria were tested by TEM. Scale, 1 μm. Yellow arrow: normal mitochondria; green arrow: pyknotic mitochondria; red arrow: swollen mitochondria. (b and c) Flow cytometry was used to detect mitochondrial membrane potential. (d) The content of ROS in serum samples of rats in each group was tested by enzyme-linked immunosorbent assay (ELISA). The generation of MDA (e) GSH-Px (f) and SOD (g) in serum samples was analyzed by corresponding commercial kits. SPID: sequela of pelvic inflammatory disease; SSD: Shipi Shugan Decoction; FQC: Fuke Qianjin Capsules; TEM: transmission electron microscopy. (versus sham), (versus sham), (versus SPID), (versus SPID), and (versus SPID). Data represent the mean ± SEM.

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