Modified Yuejuwan Inhibited Cholesterol Accumulation and Inflammation in THP-1 Macrophage-Derived Foam Cells by Inhibiting the Activity of the TRIM37/TRAF2/NF-κB Pathway

Figure 2

MYJ increased cholesterol efflux in THP-1 macrophage-derived foam cells. (a) MYJ treatment reducing oxLDL uptake in foam cells. Magnification: 200x. (b) MYJ treatment inhibiting the accumulation of TC, FC, and CE in foam cells. vs. THP-1, vs. foam + MYJ-0, vs. foam + MYJ-0. (c) The contents of IL-1β and TNF-α decreased in foam cells in the presence of MYJ. vs. THP-1; vs. foam + MYJ-0, vs. foam + MYJ-0. (d) Western blot used to examine the protein contents of SR-B1, ABCA1, ABCG1, NF-κB (cytoplasm), and NF-κB (nucleus) in cells as indicated above. vs. THP-1; vs. foam + MYJ-0.

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