Modified Yuejuwan Inhibited Cholesterol Accumulation and Inflammation in THP-1 Macrophage-Derived Foam Cells by Inhibiting the Activity of the TRIM37/TRAF2/NF-κB Pathway

Figure 5

MYJ functioned as a TRIM37 inhibitor in foam cells. (a) MYJ treatment inhibiting the uptake of oxLDL in oeTRIM37-transfected cells. Magnification: 200x. (b) The accumulations of TC, FC, and CE downregulated in oeTRIM37-transfected cells in the presence of MYJ. vs. oeNC; vs. oeTRIM37. (c) The secretion of IL-1β and TNF-α inhibited in oeTRIM37-transfected cells with the treatment of MYJ. vs. oeNC; vs. oeTRIM37. (d) Western blot used to examine the contents of SR-B1, ABCA1, ABCG1, NF-κB (cytoplasm), and NF-κB (nucleus) in cells as indicated above. vs. oeNC; vs. oeTRIM37.

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