Topical Application of Premna integrifolia Linn on Skin Wound Injury in Rats Accelerates the Wound Healing Process: Evidence from In Vitro and In Vivo Experimental Models
Table 1
Effect of PIE on wound diameter, wound area, and percentage of wound contraction in an excision wound model.
Groups
Wound diameter (mm)
Area (mm sq)
Percentage wound contraction (%)
D0
D4
D8
D12
D16
D20
D0
D4
D8
D12
D16
D20
D0
D4
D8
D12
D16
D20
Excision (control)
24.5 ± 0.58
23.7 ± 0.5
22.5 ± 0.5
15.5 ± 0.58
12.5 ± 0.58
10 ± 0.82
471.4 ± 22.2
442.9 ± 18.4
397.6 ± 20.4
188.8 ± 14.5
122.9 ± 11.3
78.9 ± 8.83
0
5.8 ± 0.87
15.51 ± 2.89
59.88 ± 3.54
73.89 ± 2.71
83.23 ± 2.97
Base
24.7 ± 0.5
23.5 ± 0.58
22.2 ± 0.43
13 ± 0.82
12.5 ± 1.29
8 ± 0.82
481 ± 19.2
433.7 ± 21.3
388.8 ± 17.7
133.1 ± 16.67
123.6 ± 12.4
50.6 ± 6.63
0
9.64 ± 1.34
19.11 ± 2.12
72.30 ± 3.57
74.13 ± 5.28
89.46 ± 2.13
Extract (PIE)
25 ± 0.5
21.5 ± 0.58
17.5 ± 1.12
10.5 ± 1.29
4 ± 1.41
0.5 ± 0.58
481 ± 19.2
363.1 ± 19.5
241.4 ± 25.5
87.5 ± 11.3
13.7 ± 2.8
0.4 ± 0.11
0
24.43 ± 3.32
49.70 ± 6.32
81.75 ± 4.6
97.15 ± 1.58
99.92 ± 0.09
STD (povidone-iodine)
24.5 ± 0.58
20 ± 1.41
15 ± 0.71
8.75 ± 0.96
2.7 ± 0.96
0
471.4 ± 22.2
315.2 ± 20.4
177 ± 19.2
60.6 ± 9.47
6.5 ± 0.9
0.0
0
32.75 ± 5.85
62.28 ± 5.49
87.20 ± 2.31
98.64 ± 0.90
100 ± 0
Values are expressed as mean ± SEM for 6 animals per group. . compared with controls (ANOVA followed by post hoc tests for multiple comparisons).
