Antitumor Effects of Delta (9)-Tetrahydrocannabinol and Cannabinol on Cholangiocarcinoma Cells and Xenograft Mouse Models

Figure 6

Effect of THC and CBN on tumor growth in HuCCT1 xenograft mice. (a) Development of the body weight of nude mice. (b) Tumor growth curve of control mice treated with 15 mg/kg THC, 30 mg/kg THC, 20 mg/kg CBN, and 40 mg/kg CBN. The growth of tumors in HuCCT1 xenograft mice treated with THC significantly decreased compared with control mice (, versus control mice). (c) Tumors of xenograft mice after 21 d of treatment with (i) control, (ii) 15 mg/kg THC, (iii) 30 mg/kg THC, (iv) 20 mg/kg CBN, and (v) 40 mg/kg CBN. (d) Survival curve indicating the percentage of mice with tumor volumes less than 400 mm³. THC concentrations of 15 mg/kg and 30 mg/kg significantly inhibited tumor growth in the HuCCT1 xenograft mice compared to the control mice ( for 15 mg/kg THC and for 30 mg/kg THC versus control mice).

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