Research Article

Shikonin Mediates Apoptosis through G Protein-Coupled Estrogen Receptor of Ovarian Cancer Cells

Figure 4

. Western blot analysis of estrogen membrane receptor (GPER) signaling pathway proteins. (a, b) Western blot result of proteins related to GPER/EGFR/PI3K/AKT pathway of SKOV3 cells treated with 5 and 10 μM SK for 24 h. (c, d) Western blot results for proteins related to the GPER/EGFR/PI3K/ AKT pathway in A2780 cells treated with 0.5 and 1.0 μM SK for 24 h. The results are means of three independent replicates ± S.D. or vs. control group were considered as statistically significantly.
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