Systematic Review of the Efficacy and Safety of Shuxuening Injection in the Treatment of Unstable Angina

Table 1

Literature search.

Study IDs	Sample size		Duration (days)	Intervention		Age		Gender		Outcomes
	T	C		T	C	T	C	M	F
Chen and Sun 2018 [6]	33	33	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	58.1 ± 2.0	57.8 ± 2.4	—	—	③
Qiu 2018 [7]	30	30	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	72.4 ± 2.3	70.9 ± 2.2	24	36	①⑧⑨
Liu 2018 [8]	40	40	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	58.76 ± 4.50	58.90 ± 4.72	46	34	②③⑤⑥
Zhang 2017 [9]	42	40	30	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	55 ± 6	53 ± 9	48	34	①
Wu 2016 [10]	40	40	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	61.2 ± 3.1	61.5 ± 3.2	49	31	①②③⑤⑥
Zheng and Li 2015 [11]	49	49	20	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	43	55	①⑤⑦
Li et al. 2015 [12]	36	36	28	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	64.3 ± 1.2	63.1 ± 1.3	39	33	①⑧
Liu 2015 [13]	42	42	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	60.5 ± 3.2	61.3 ± 3.4	49	35	①②③⑤⑥⑨
Liu and Cheng 2015 [14]	48	48	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	59.38 ± 6.22	54.87 ± 4.95	57	39	①⑤⑧
Zhu 2014 [15]	48	48	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	63.8 ± 11.2	64.1 ± 10.8	56	40	①⑤⑧
He et al. 2014 [16]	62	60	28	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	55.80 ± 3.14	52.80 ± 2.90	63	59	①⑤⑦⑧⑨
Zhang 2013 [17]	42	40	15	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	54 ± 8	55 ± 8	48	34	①④
Liu and Zhang 2013 [18]	50	50	14	Basic care + Shuxueninginjection25 ml, ivgtt, qd	Basic care	58.7 ± 6.5	57.9 ± 5.3	53	47	①⑤⑥
Geng 2013 [19]	26	26	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	59.5 ± 7.6	58.2 ± 8.3	29	23	①⑨
Lei and Xiao 2013 [20]	50	50	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	56.3 ± 2.6	55.6 ± 2.5	70	30	①⑧⑨
Liu and Wei 2013 [21]	60	60	14	Basic care + Shuxueninginjection10 ml, ivgtt, qd	Basic care	—	—	62	58	①⑧⑨
Ma and Yao 2012 [22]	53	49	10	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	68.79 ± 10.31	68.12 ± 10.27	67	35	④⑧⑨
Tao and Chen 2012 [23]	36	32	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	36	32	①⑧⑨
Zhuang 2012 [24]	34	34	14	Basic care + Shuxueninginjection10 ml, ivgtt, qd	Basic care	—	—	41	27	①⑨
Yan 2011 [25]	68	68	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	76	60	①⑨
Sui 2011 [26]	30	30	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	36	24	①②⑤
Gao and Feng 2011 [27]	36	33	15	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	43	26	①②③④⑨
Li 2011 [28]	400	400	15	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	58.20 ± 5.90	58.70 ± 6.20	430	370	①
Chai 2010 [29]	58	42	7	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	64.3 ± 2.3	62.6 ± 1.9	64	36	①⑦⑧⑨
Guo 2010 [30]	30	30	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	—	—	①⑨
Wang 2010 [31]	45	45	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	—	—	—	—	①⑧⑨
Zhang et al. 2008 [32]	48	48	15	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	63.8 ± 11.2	64.1 ± 10.8	54	42	①⑧⑨
Xi 2009 [33]	48	40	14	Basic care + Shuxueninginjection20 ml, ivgtt, qd	Basic care	56.3 ± 7.8	55.1 ± 4.5	50	38	①⑧⑨

Note: ①: clinical effect of angina; ②: angina frequency; ③: duration of angina; ④: nitroglycerin dosage; ⑤: C-reactive protein; ⑥: brain natriuretic peptide; ⑦: blood fat; ⑧: improvement of electrocardiogram; ⑨: adverse drug reactions or adverse events.