Evidence-Based Complementary and Alternative Medicine

Research Article

Antioxidant, Enzyme Inhibitory, and Molecular Docking Approaches to the Antidiabetic Potentials of Bioactive Compounds from Persicaria hydropiper L.

Table 1

Results of α-glucosidase/α-amylase inhibitory assays.


Samples	α-Glucosidase inhibition assay			α-Amylase Inhibition assay
Samples	Conc. µg·mL⁻¹	% enzyme inhibition	IC₅₀µg·mL⁻¹	Conc. µg·mL⁻¹	% enzyme inhibition	IC₅₀µg·mL⁻¹

Ph-1	1000 500 250 125 62.50	81.84 ± 0.32^ns 75.68 ± 0.22 ^ns 67.54 ± 0.16 ^ns 52.83 ± 1.07 ^ns 39.54 ± 0.46	85	1000 500 250 125 62.50	75.83 ± 1.07 ^ns 69.54 ± 0.46 ^ns 64.36 ± 0.21 ^ns 55.84 ± 0.32 ^ns 48.68 ± 0.22 ^ns	69.48
Ph-2	1000 500 250 125 62.50	78.79 ± 0.63 ^ns 70.67 ± 0.61 ^ns 51.69 ± 0.77 44.54 ± 0.50 24.00 ± 0.30	170	1000 500 250 125 62.50	71.62 ± 0.74 ^ns 63.86 ± 0.60 ^ns 44.48 ± 0.64 37.54 ± 0.50 31.74 ± 0.61	252.01
Ph-3	1000 500 250 125 62.50	55. 44 ± 0.09 51. 10 ± 0.33 45. 93 ± 0.45 41. 64 ± 0.13 34. 00 ± 0.31	474.83	1000 500 250 125 62.50	57.33 ± 0.88 53.00 ± 0.57 48.96 ± 1.91 43.00 ± 1.73 37.66 ± 1.36	332.19
Ph-4	1000 500 250 125 62.50	64.36 ± 0.61 53.40 ± 0.52 39.46 ± 0.60 22.52 ± 0.49 17.52 ± 0.71	455.94	1000 500 250 125 62.50	72.51 ± 0.62^ns 63.44 ± 0.44 ^ns 42.46 ± 0.47 23.68 ± 0.64 19.31 ± 0.57	333.25
Ph-5	1000 500 250 125 62.50	67.37 ± 0.68 61.58 ± 0.74 56.65 ± 0.77 47.55 ± 0.77 43.46 ± 0.63	228	1000 500 250 125 62.50	64.23 ± 0.44 57.45 ± 0.65 52.37 ± 0.64 47.37 ± 0.54 42.30 ± 0.61	370
Ph-6	1000 500 250 125 62.50	58. 91 ± 1.54 54. 49 ± 0.14 48. 89 ± 0.20 41. 43 ± 0.29 37.23 ± 0.44	337.94	1000 500 250 125 62.50	61.33 ± 0.88 55.00 ± 0.57 50.96 ± 1.91 43.00 ± 1.73 36.09 ± 0.32	271.24
P. Control	1000 500 250 125 62.50	89.42 ± 0.55 77.52 ± 0.62 71. 36 ± 0.49 62.39 ± 0.49 55.47 ± 0.52	40	1000 500 250 125 62.50	85.72 ± 0.66 78.60 ± 0.46 73.62 ± 0.40 65.48 ± 0.74 59.36 ± 0.57	45

For the statistical difference among the test samples and positive control, one-way ANOVA followed by multiple comparison Dunnett’s test was applied to the data. , , , and ns: values not significantly different when compared with standard drug inhibitions (Acarbose) at the same tested concentrations.