Integrated UPLC-Q-TOF-MS/MS and Network Pharmacology Approach to Investigating the Metabolic Profile of Marein of Coreopsis tinctoria Nutt.

Table 5

Relevant topological information of 15 key targets.

NO.	Uniprot ID	Gene name	Protein name	BC	CC	Degree
1	P12931	SRC	Proto-oncogene tyrosine-protein kinase SRC	0.0671	0.4160	34
2	P31749	AKT1	RAC-alpha serine/threonine-protein kinase	0.0971	0.4325	33
3	P00533	EGFR	Epidermal growth factor receptor	0.0702	0.4067	31
4	P01112	HRAS	GTPase HRas	0.0680	0.4022	31
5	P07900	HSP90AA1	Heat shock protein HSP 90-alpha	0.0494	0.4000	29
6	P45983	MAPK8	Mitogen-activated protein kinase 8	0.0664	0.3978	29
7	P05019	IGF1	Insulin-like growth factor I	0.0669	0.4160	27
8	P61586	RHOA	Transforming protein RhoA	0.0379	0.3872	26
9	P29474	NOS3	Nitric oxide synthase	0.0775	0.4007	24
10	P10275	AR	Androgen receptor	0.0542	0.3949	23
11	P03372	ESR1	Estrogen receptor	0.0464	0.4090	22
12	P02768	ALB	Albumin	0.0796	0.4113	21
13	Q06124	PTPN11	Tyrosine-protein phosphatase nonreceptor type 11	0.0072	0.3765	21
14	P17612	PRKACA	cAMP-dependent protein kinase catalytic subunit alpha	0.0389	0.3664	21
15	P42574	CASP3	Caspase-3	0.0544	0.3956	20