Taohong Siwu Decoction Promotes Osteo-Angiogenesis in Fractures by Regulating the HIF-1<i>α</i> Signaling Pathway

<div>TSD promotes angiogenesis by regulating the HIF-1<i>α</i> signaling pathway. (a) Quantitative analysis for the mRNA level of VHL, HIF-1<i>α</i>, VEGF, and Ang-2. (b) The protein expression levels of pVHL, HIF-1<i>α</i>, VEGF, and Ang-2 were analyzed by western blot. ns: no statistical significance, <svg height="10.7395pt" id="M37" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 68.3436 10.7395" width="68.3436pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 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27V0H384Z"></path></g></svg> vs. the control serum group. <sup>###</sup><svg height="9.2729pt" id="M38" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -8.6359 51.1027 9.2729" width="51.1027pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M600 480C600 590 528 650 384 650H143L137 622C222 614 225 607 210 531L130 127C113 41 106 36 23 28L17 0H294L300 28C204 36 195 42 212 127L243 284L314 263C327 263 339 263 352 264C465 271 600 337 600 480ZM508 481C508 351 402 304 329 304C289 304 265 311 250 317L295 559C302 594 310 606 323 611C335 616 350 619 367 619C455 619 508 573 508 481Z"></path></g><g transform="matrix(.013,0,0,-0.013,11.658,0)"><path d="M512 -3V55L134 254V256L512 456V514L75 281V230L512 -3Z"></path></g><g transform="matrix(.013,0,0,-0.013,22.921,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 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TSD: Taohong Siwu decoction; HIF-1<i>α</i>: hypoxia-inducible factor-1<i>α</i>; VHL: von Hippel-Lindau tumor suppressor; VEGF: vascular endothelial growth factor; and Ang-2: angiopoietin-2.</div>

Evidence-Based Complementary and Alternative Medicine

fig4

Figure 4

Figure 4: Taohong Siwu Decoction Promotes Osteo-Angiogenesis in Fractures by Regulating the HIF-1<i>α</i> Signaling Pathway 

Evidence-Based Complementary and Alternative Medicine

Taohong Siwu Decoction Promotes Osteo-Angiogenesis in Fractures by Regulating the HIF-1α Signaling Pathway

Figure 4