Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-<i>β</i> Signalling Activation to Ameliorate Myocardial Fibrosis

<div>BEL prevented ISO-induced elevations in Collagen I, Collagen III, <i>α</i>-SMA, and SOX9 in mice. (a) Immunohistochemical staining examined the expression of Collagen I and Collagen III. (b) Western blot analysed the expression of <i>α</i>-SMA, Collagen I, and Collagen III. (c–e) The fold changes of <i>α</i>-SMA, Collagen I, and Collagen III were shown by bar graphs; GAPDH was used as a loading control (<i>n</i> = 3). (f) Detecting the expression of SOX9 using Western blot. (g) The fold changes of SOX9 were presented by bar graphs. GAPDH was used as a loading control (<i>n</i> = 3). 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-12Z"></path></g><g transform="matrix(.013,0,0,-0.013,31.809,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.049,0)"><path d="M153 550H386L412 615L406 623H120L82 318C104 327 142 338 184 338C294 338 347 275 347 187C347 112 305 39 221 39C160 39 119 71 97 89C88 97 80 96 71 90C59 80 50 67 49 57C48 45 52 36 66 23C80 9 123 -12 169 -12C221 -11 288 15 342 59C403 109 431 165 431 225C431 308 366 395 238 395C212 395 165 379 127 364L153 550Z"></path></g></svg> and <sup>##</sup><svg height="11.7782pt" id="M19" style="vertical-align:-3.42938pt" version="1.1" viewbox="-0.0498162 -8.34882 44.5261 11.7782" width="44.5261pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 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transform="matrix(.013,0,0,-0.013,31.809,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,38.049,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg> vs. ISO.</div>

Evidence-Based Complementary and Alternative Medicine

fig7

Figure 7

Figure 7: Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-<i>β</i> Signalling Activation to Ameliorate Myocardial Fibrosis 

Evidence-Based Complementary and Alternative Medicine

Bellidifolin Inhibits SRY-Related High Mobility Group-Box Gene 9 to Block TGF-β Signalling Activation to Ameliorate Myocardial Fibrosis

Figure 7