Research Article
[Retracted] Elevated Plasma Interleukin-35 as a Prognostic Indicator in Localized Clear Cell Renal Cell Carcinoma
Table 1
Baseline characteristics of patients with localized RCC (n = 50) according to the IL-35.
| | Characteristics | Patients (n = 50) | Group 1
low IL-35
(n = 30) | Group 2
high IL-35
(n = 20) | value
two-side |
| | OS-time | 65.30 ± 12.84 | 69.10 ± 5.22 | 59.60 ± 18.06 | 0.0089 | | PFS-time | 61.58 ± 16.83 | 67.90 ± 8.01 | 52.10 ± 21.79 | 0.0007 | | Age (mean ± SD) | 56.82 ± 14.26 | 59.00 ± 12.19 | 53.55 ± 16.71 | 0.1885 | | ≤65 | 39 | 23 | 16 | 0.78 | | >65 | 11 | 7 | 4 | | | Sex (male/female) | 31/19 | 19/11 | 12/8 | 0.812 | | BMI (kg/m2) (≤24/>24) | 32/18 | 17/13 | 15/5 | 0.186 | | Hypertension (yes/no) | 26/24 | 12/18 | 14/6 | 0.038 | | Diabetes (yes/no) | 6/44 | 4/26 | 2/18 | 0.722 | | Family history (yes/no) | 3/47 | 1/29 | 2/18 | 0.331 | | Symptom (yes/no) | 36/14 | 26/4 | 10/10 | 0.005 | | Tumor size (cm) (mean ± SD) | 4.21 ± 1.98 | 3.69 ± 1.22 | 5.01 ± 2.60 | 0.0203 | | ≤4 cm | 25 | 17 | 8 | 0.248 | | >4 cm | 25 | 13 | 12 | | | Surgical procedure (PN/RN) | 14/36 | 9/21 | 5/15 | 0.700 | | T classification (I/II) | 46/4 | 30/0 | 16/4 | 0.043 | | Nuclear grade (1-2/3-4) | 32/18 | 23/7 | 9/11 | 0.022 | | Necrosis (yes/no) | 3/47 | 0/30 | 3/17 | 0.114 | | IL-35 | 110.42 ± 61.96 | 73.28 ± 14.98 | 166.15 ± 64.12 | ＜0.0001 | | 3-year OS rate (%) | 94.00% (47/50) | 100.00% (30/30) | 85.00% (17/20) | 0.114 | | 3-year PFS rate (%) | 86.00% (43/50) | 96.67% (29/30) | 70.00% (14/20) | 0.025 | | 5-year OS rate (%) | 88.00% (44/50) | 100.00% (30/30) | 70.00% (14/20) | 0.006 | | 5-year PFS rate (%) | 76.00% (38/50) | 90.00% (27/30) | 55.00% (11/20) | 0.012 |
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OS: overall survival; PFS: progression-free survival. BMI: body mass index. PN: partial nephrectomy; RN: radical nephrectomy. . |
