Research Article
Multitech-Based Study on Medicinal Material Basis and Action Mechanism of Herbal Formula Xian-Ling-Gu-Bao Capsule in Treatment of Osteoarthritis
Figure 6
XLGB protected ATDC5 cells against LPS-induced apoptosis. (a) Effects of XLGB on cell viability of chondrocytes. The concentrations of XLGB for treatment ranged from 2.5 to 100 μg/mL. (b) Effects of XLGB on cell viability of LPS-induced chondrocytes. The concentrations of XLGB for treatment ranged from 5 to 50 μg/mL. (c) Effects of XLGB (25 μg/mL) on apoptosis of LPS-induced chondrocytes. (d) Effects of XLGB (25 μg/mL) on the expression of apoptosis-relevant proteins in LPS-induced chondrocytes. ATDC5 cells were treated with 5 μg/mL of LPS for 12 h. For drug administration, the cells were treated with XLGB extracts for 12 h before LPS stimulation. , , and compared with the control group; , , and compared with the LPS group (XLGB, Xian-Ling-Gu-Bao; LPS, lipopolysaccharide).
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