Research Progress on the Effect of Traditional Chinese Medicine on Signal Pathway Related to Premature Ovarian Insufficiency

Table 1

The regulatory effects of Traditional Chinese medicine on signal pathways related to POI.

Chinese herbal	Sources	Classification	Efficacies	Pathways	Targets	Experimental model	Roles
Ginsenoside Rg1 [10]	Ginseng	Qi tonics	It is a great tonic for the vital energy, restores the pulse, and fixes the detachment, tonifies the spleen, benefits the lung, generates fluid and nourishes the blood, and calms the mind.	PI3K/Akt/mTOR signaling pathways	PI3K↓, Akt↓, mTOR↓, S6k↓	SPF-grade female BALB/c mice	Activation of autophagy in ovarian tissues to inhibit the onset of aging.
Epimedium glycoside [11]	Epimedium	Yang tonics	Tonifying the kidney and Yang, strengthening the muscles and bones, dispelling wind and dampness.	PI3K/Akt/mTOR signaling pathways	PI3K/Akt/mTOR↑	Clean-grade female uncrossed Wistar rats	Inhibit oxidative stress and reduces tissue apoptosis.
Cistanche [53]	The fleshy stems of Cistanche or Cistanche, Cistanche fannii, etc., of the family Cistanaceae.	Yang tonics	Tonifying the kidney and Yang, benefiting the essence and blood, moistening the intestines, and opening the bowels.	NF-kB signaling pathways	TNF-α↓, IFN-γ↓, Bcl-2↑, Bax↓	SPF-grade 12-week-old SD female rats	Reduce follicular atresia and apoptosis, which in turn slows ovarian failure.