Antrodia salmonea Extracts Regulate p53-AR Signaling and Apoptosis in Human Prostate Cancer LNCaP Cells

Figure 6

Schematic diagram of AS-mediated regulation of apoptosis in prostate cancer. AS enhances p53 protein stability and nuclear accumulation in androgen-dependent human prostate cancer cells. Increased p53 inhibits both the Ser-81 phosphorylation and protein stability of AR in the nucleus. Decreased protein expression/activation of AR through p53 upregulation, therefore, causes apoptotic features in prostate cancer cells. Besides, AS-mediated p53 activation results in cell cycle inhibition. Overall, AS inhibits prostate cancer cell proliferation through p53 regulation and AR inhibition.