Antidepressant Mechanism of Kaixinsan and Its Active Compounds Based on Upregulation of Antioxidant Thioredoxin

Table 1

Summary of compounds in KXS (I: compounds with a tetracyclic skeleton-like cortisol and testosterone; II: structural analogs of catecholamines or tyrosine; III: structural analogs of resolvins).

Mol ID	Compound	Herb	OB (%)	DL	Chemical formula	Chemical group
MOL002879	Diop	Ginseng Radix	43.59	0.39	C24H38O4	III
MOL000449	Stigmasterol	Ginseng Radix	43.83	0.76	C29H48O	I
MOL000358	Beta-sitosterol	Ginseng Radix	36.91	0.75	C29H50O	I
MOL003648	Inermin	Ginseng Radix	65.83	0.54	C16H12O5	II
MOL000422	Kaempferol	Ginseng Radix Acori Tatarinowii Rhizoma	41.88	0.24	C15H10O6	II
MOL005308	Aposiopolamine	Ginseng Radix	66.65	0.22	C17H19NO3	II
MOL005317	Deoxyharringtonine	Ginseng radix	39.27	0.81	C28H37NO8	II
MOL005318	Dianthramine	Ginseng radix	40.45	0.20	C14H11NO6	II
MOL005320	Arachidonate	Ginseng radix	45.57	0.20	C20H32O2	III
MOL005321	Frutinone A	Ginseng Radix、Polygalae Radix	65.9	0.34	C16H8O4	II
MOL005344	Ginsenoside rh2	Ginseng Radix	36.32	0.56	C36H62O8	I
MOL005348	Ginsenoside-Rh4	Ginseng Radix	31.11	0.78	C36H60O8	I
MOL005356	Girinimbin	Ginseng Radix	61.22	0.31	C18H17NO	II
MOL005376	Panaxadiol	Ginseng Radix	33.09	0.79	C30H52O3	I
MOL005384	Suchilactone	ginseng Radix	57.52	0.56	C21H20O6	II
MOL005399	Alexandrin	Ginseng Radix	36.91	0.75	C35H60O6	I
MOL000787	Fumarine	Ginseng Radix	59.26	0.83	C20H19NO5	II
MOL000273	(2R)-2-[(3S 5R 10S 13R 14R 16R 17R)-3,16-Dihydroxy-4 4 10 13 14-pentamethyl-2 3 5 6 12 15 16 17-octahydro-1H-cyclopenta[a]phenanthren-17-yl]-6-methylhept-5-enoic acid	Poria	38.26	0.82	C30H46O4	I
MOL000275	Trametenolic acid	Poria	38.71	0.80	C30H48O3	I
MOL000279	Cerevisterol	Poria	37.96	0.77	C28H46O3	I
MOL000282	Ergosta-7 22E-dien-3beta-ol	Poria	43.51	0.72	C28H46O	I
MOL000283	Ergosterol peroxide	Poria	40.36	0.81	C28H44O3	I
MOL000296	Hederagenin	Poria	36.91	0.75	C30H48O4	I
MOL002140	Perlolyrine	Polygalae Radix	65.95	0.27	C16H12N2O2	II
MOL004718	α-Spinasterol	Polygalae Radix	42.98	0.76	C29H48O	I
MOL013171	1 6-Dihydroxy-3 7-dimethoxyxanthone	Polygalae Radix	89.65	0.27	C15H12O6	II
MOL003152	1 7-Dihydroxy-3-methoxy xanthone	Polygalae Radix	64.06	0.21	C14H10O5	II
MOL003542	8-Isopentenyl-kaempferol	Acori Tatarinowii Rhizoma	38.04	0.39	C20H18O6	II
MOL003576	(1R 3aS 4R 6aS)-1 4-bis (34-dimethoxyphenyl)-1 3 3a 4 6 6a-hexahydrofuro [4 3-c] furan	Acori Tatarinowii Rhizoma	52.35	0.62	C22H26O6	II
MOL003578	Cycloartenol	Acori Tatarinowii Rhizoma	38.69	0.78	C30H50O	I