Marsdenia tenacissima Extract Induces Autophagy and Apoptosis of Hepatocellular Cells via MIF/mToR Signaling

Figure 1

MTE suppressed the proliferation of the MHCC-97H and HepG2 cells in a dose- and time-dependent manner. (a, b) The MHCC-97H and HepG2 cells were stimulated with various concentrations of MTE (0, 12.5, 25, 50, 100, 200, and 400 mg/mL) for 24 h, 48 h, and 72 h. The cell viabilities of (a) the MHCC-97H and (b) HepG2 were assessed by MTT assay. (c) The cellular morphologies of the MHCC-97 cells in the control and MTE treatment group (35 mg/mL) were observed using electron microscopy (×40). (d) The cellular morphologies of the HepG2 cells in the control and MTE treatment group (50 mg/mL) were observed using electron microscopy (×40). n = 5.

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