The Efficacy and Safety of Xinjia Xuanbai Chengqi Granules in Acute Exacerbation of COPD: A Multicentre, Randomised, Double-Blind, Controlled Trial
Table 3
Comparison of outcomes after intervention.
Variable
Group
D6–baseline
Baseline
D6
value
TCM syndrome score
Group A (n = 106)
23.32 ± 6.74
9.11 ± 6.18#
−14.21 ± 7.29
<0.0001
Group B (n = 107)
22.99 ± 7.44
9.84 ± 6.30
−13.15 ± 7.42
<0.0001
Group C (n = 110)
22.53 ± 6.34
11.54 ± 6.52
−10.99 ± 8.36
<0.0001
Phlegm
Group A (n = 106)
1.63 ± 0.81
0.64 ± 0.57
−0.99 ± 0.81
<0.0001
Group B (n = 107)
1.68 ± 0.73
0.71 ± 0.61
−0.97 ± 0.81
<0.0001
Group C (n = 110)
1.57 ± 0.80
0.86 ± 0.77
−0.71 ± 1.09
<0.0001
mMRC
Group A (n = 106)
2.35 ± 0.81
1.42 ± 0.99
−0.93 ± 0.89
<0.0001
Group B (n = 107)
2.38 ± 0.75
1.50 ± 0.83
−0.88 ± 0.75
<0.0001
Group C (n = 110)
2.25 ± 0.84
1.56 ± 0.90
−0.69 ± 0.89
<0.0001
Wexner
Group A (n = 106)
7.17 ± 3.56
3.25 ± 2.71
−3.92 ± 2.69
<0.0001
Group B (n = 107)
7.55 ± 3.71
3.75 ± 3.00
−3.80 ± 3.28
<0.0001
Group C (n = 110)
7.05 ± 3.64
4.11 ± 3.48
−2.95 ± 3.03
<0.0001
pH
Group A (n = 100)
7.41 ± 0.03
7.40 ± 0.03
−0.00 ± 0.03
0.1212
Group B (n = 96)
7.40 ± 0.04
7.40 ± 0.04
−0.00 ± 0.03
0.4060
Group C (n = 104)
7.40 ± 0.04
7.40 ± 0.04
−0.00 ± 0.03
0.5197
PaO2
Group A (n = 100)
75.49 ± 20.79
80.81 ± 23.28
4.49 ± 18.39
0.0165
Group B (n = 96)
76.30 ± 21.07
78.63 ± 26.01
1.87 ± 26.44
0.4896
Group C (n = 104)
77.19 ± 30.49
78.53 ± 23.72
0.91 ± 31.60
0.7703
PaCO2
Group A (n = 100)
41.55 ± 9.44
42.25 ± 9.10
0.68 ± 4.70
0.1488
Group B (n = 96)
42.73 ± 9.92
43.65 ± 12.62
1.10 ± 7.10
0.1313
Group C (n = 104)
42.54 ± 14.35
43.45 ± 14.11
1.00 ± 5.36
0.0596
CRP
Group A (n = 101)
11.98 ± 29.33
8.27 ± 23.02
−3.61 ± 17.50
0.0408
Group B (n = 102)
16.12 ± 33.67
9.35 ± 30.50
−6.60 ± 28.62
0.0218
Group C (n = 103)
15.60 ± 35.21
8.13 ± 23.61
−7.44 ± 24.03
0.0022
PCT
Group A (n = 102)
0.09 ± 0.16
0.08 ± 0.15
−0.02 ± 0.28
0.4015
Group B (n = 100)
0.09 ± 0.11
0.08 ± 0.10
−0.02 ± 0.12
0.0926
Group C (n = 103)
0.06 ± 0.06
0.07 ± 0.06
−0.00 ± 0.06
0.4863
IL6
Group A (n = 93)
12.35 ± 21.63
11.02 ± 13.91
−0.77 ± 17.53
0.6730
Group B (n = 94)
11.58 ± 17.60
25.41 ± 139.20
15.01 ± 142.62
0.3103
Group C (n = 98)
21.84 ± 101.39
10.14 ± 14.05
−12.72 ± 101.52
0.2177
TNF-α
Group A (n = 91)
14.37 ± 29.37
14.04 ± 29.01
−0.30 ± 24.16
0.9044
Group B (n = 92)
72.41 ± 235.71
59.68 ± 210.30
−10.49 ± 209.31
0.6319
Group C (n = 100)
49.39 ± 181.27
32.40 ± 139.82
−15.91 ± 177.03
0.3711
Note. , group A compared with group C; #. D6: the day after intervention; TCM: traditional Chinese medicine; mMRC: modified British medical research council.
