Research Article

Insecticidal, Antimalarial, and Antileishmanial Effects of Royal Jelly and Its Three Main Fatty Acids, trans-10-Hydroxy-2-decenoic Acid, 10-Hydroxydecanoic Acid, and Sebacic Acid

Table 4

Antileishmanial activity of royal jelly and its three main fatty acids (trans-10-hydroxy-2-decenoic acid (10-H2DA), 10-hydroxydecanoic acid (10-HDAA), and sebacic acid (1,10-decanedioic acid)) against intracellular amastigotes of Leishmania major.

DrugAntileishmanial effect IC50 (μg/mL)

Royal jelly8.4 ± 0.74
10-H2DA3.8 ± 0.22
10-HDAA3.77 ± 0.46
Sebacic acid4.13 ± 0.51
Meglumine antimoniate13.6 ± 1.15

Data are presented as the mean ± SD.