NBP Relieves Cardiac Injury and Reduce Oxidative Stress and Cell Apoptosis in Heart Failure Mice by Activating Nrf2/HO-1/Ca²⁺-SERCA2a Axis

Figure 2

NPB alleviated oxidative stress injury and decreased the apoptosis of cardiomyocytes of heart failure mice. (a) The levels of ROS in mice was examined by IFA (scale bar = 20 µm); (b) The level of MDA, SOD, and CAT of plasma examined by ELISA assay; (c) The TUNEL staining results demonstrated the rat myocardial apoptosis (scale bar = 20 µm); (d) Bax and Bcl-2 identified using Western blotting; ‘’. N = 15.

(a)

(b)

(c)

(d)